Internal Medicine Pharmacotherapy

Andexanet alfa (Andexxa) made its quiet exit from the U.S. market just a few weeks ago.  It's an interesting story so in case you missed...

Thiamine is a water-soluble vitamin that is an important coenzyme for various metabolic processes in the body.   These include the regulat...

A 65 year old male is being treated for an infection on his forearm that developed purulent drainage within the last few days.  He denies ...

Thrombocytopenia is a notable adverse effect of linezolid.  Some of the evidence behind the onset, duration, and the extent of platelet de...

A 77 year old black patient is admitted to the hospital for a gastrointestinal bleed.  He has a past medical history of CAD (MI 15 years a...

A 65 year old patient with COPD sees his primary care provider for worsening shortness of breath over the past week.  His current medicati...

Heparin and low molecular weight heparins (LMWH) are some of the many medications that have been identified to cause hyperkalemia.  When l...

Let's start with a patient case.  A 58 year old male is sent to the hospital from his PMD for hyperkalemia.  He has a past medical his...

Last year, the FDA issued a drug safety communication , warning about the risk of nerve damage from fluoroquinolone antibiotics.  You can ...

An earlier post discussed how to bridge argatroban to warfarin in patients with HIT  but didn't cover how to determine the likelihood...

A question recently came up regarding the risk of serotonin toxicity from a drug interaction between procarbazine and a number of differen...

In a previous blog post, niacin for dyslipidemia , we discussed the concerns regarding niacin's lack of improvement of clinically mean...

There has been concern in recent years regarding cardiovascular risk in patients using azithromycin which I discussed in an earlier post f...

Let’s start with a patient case.  An 82 year old female patient presents to clinic with complaints of weakness in her lower extremities. ...

The management of anticoagulant therapy is an important component of the treatment of various disease states. Maintaining the narrow ther...

Niacin is one of our options for managing cholesterol in patients with dyslipidemia.   The benefits of high doses of niacin are well esta...

Bleeding risk with anticoagulant and antiplatelet medications is something that we struggle with on a regular basis.   Should we fully anti...

Since 2012, the FDA has made two statements regarding the safety of azithromycin related to cardiovascular risk.  These warnings were large...

This week’s pharmacy pearl describes a recent alert from the FDA that you might have heard about regarding fluoroquinolones.   Fluoroquin...

Linezolid is an oxazolidinone antibiotic (see more about its mechanism here ) that is active against many gram-positive organisms inclu...