This week, the RE-ALIGN
study was published in the New England Journal of Medicine, examining the use
of dabigatran in patients undergoing a mechanical valve replacement or who
underwent one at least three months earlier.
This study was a dose-finding study for dabigatran primarily looking at
plasma trough concentrations in patients receiving 150-300 mg po bid depending
on renal function (Yes, higher than doses used for atrial fibrillation). The pharmacokinetic model used in the RE-LY
study (the >18,000 patient study resulting in approval of dabigatran) was
used to target certain trough concentrations and dabigatran titration was
performed at prespecified intervals.
Sunday, September 15, 2013
Sunday, September 1, 2013
Egg allergy and the 2013 Influenza vaccine
Let’s start with a patient case. A 55 year old female patient is seen in clinic that has
recently been diagnosed with COPD. After
suffering from influenza last year, she is now seeking the influenza
vaccine. Upon further questioning, the
patient confirms she is allergic to eggs.
When she eats eggs, she develops hives but no other symptoms. What can we tell her?
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